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Bioshock 3.
Irrational Games and 2K Games have announced Bioshock Infinite, another title in the Bioshock franchise. The game is set during 1912 in a new city, Columbia, which floats among the clouds. Planned for release in 2012, Bioshock Infinite will be available on XBox 360, PS3 and PC.

“We are excited to expand the world of BioShock, which is one of the industry’s most critically acclaimed and beloved franchises,” said Christoph Hartmann, president of 2K. “We believe that Irrational Games will lend their meticulous attention to detail and unique storytelling expertise to make BioShock Infinite an incredible entertainment experience that will immerse new and diehard fans of BioShock alike.”

Originally conceived as a floating symbol of American ideals at a time when the United States was emerging as a world power, Columbia is dispatched to distant shores with great fanfare by a captivated public. What begins as a brand new endeavor of hope turns drastically wrong as the city soon disappears into the clouds to whereabouts unknown.

The player assumes the role of former Pinkerton agent Booker DeWitt, sent to the lost city to rescue Elizabeth, a young woman imprisoned there since childhood. He develops a relationship with Elizabeth, augmenting his abilities with hers so the pair may escape from a city that is literally falling from the sky. DeWitt must learn to fight foes in high-speed Sky-Line battles, engage in combat both indoors and amongst the clouds, and harness the power of dozens of new weapons and abilities.
(Press Release)

Bradley Beeck: There's a distinct Bioshock 2 feel to that description - working with a partner.